Mouse Anti-Human Enteropeptidase

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Cat-Nr.101-M388
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#8S12)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant Enteropeptidase (also called Enterokinase). The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. This antibody was selected for its ability to detect human Enteropeptidase heavy chain.
Antigenhuman recombinant Enteropeptidase (also called Enterokinase)
ApplicationWB
SynonymsTMPRSS15; ENTK; PRSS7; Enterokinase; Serine protease 7; Transmembrane protease serine 15
DescriptionEnteropeptidase/Enterokinase initiates activation of pancreatic proteases by converting trypsinogen to trypsin, which in turn activates chymotrypsin, carboxypeptidases and elastases. Located in intestinal brush border, it is a disulfide bond linked dimer of the heavy and light chains, which are derived from the same single-chain precursor. The multi-domain-containing the heavy chain consists of a short cytoplasmic tail, a transmembrane, a SEA, a SRCR, a MAM, two CUB and two LDL-receptor class A domains. The light chain contains the catalytic domain of trypsin-like serine proteases.
Uniprot IDP98073
Protein RefSeqNP_002763.2
mRNA RefSeqNM_002772.2

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