Rat Anti-Mouse LIMP-II

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#1K53)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of LIMP-II.
Antigenrecombinant mouse LIMP-II
SynonymsScarb2; LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik
DescriptionLysosomes are intracytoplasmic organelles that are found within leukocytes (granulocytes, neutrophils, basophils and eosinophils) and function as storage granules for small particles. Lysosomes actively support subcellular protein degradation mechanisms through fusion with cellular organelles such as phagocytic vacuoles and the plasma membrane. Lysosome fusion to the plasma membrane, known as exocytosis, releases the contents of the vesicle into the extracellular environment. The lysosomal integral membrane proteins I–III, known as LIMP-I, LIMP-II and LIMP-III, localize from the trans-Golgi network to lysosomes via an AP-3-dependent pathway that may involve AP-1 and Clathrin. LIMP I-III are protein markers for the lysosome organelle. These markers are exceptionally useful for microscopy studies, cellular fractionation validation and studies pertaining to protein trafficking through the secretory pathway.
Uniprot IDO35114
Protein RefSeqNP_031670.1
mRNA RefSeqNM_007644.3

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