Rat Anti-Mouse IL-1 R1

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#11B7)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant extracellular domain of mouse IL-1 R1 protein. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenextracellular domain of mouse IL1R-I
SynonymsIl1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1
DescriptionIL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.
Uniprot IDP13504
Protein RefSeqNP_032388.1
mRNA RefSeqNM_008362.2

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