Rat Anti-Human Follistatin like-protein 1/FSTL1

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Cat-Nr.101-M422
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#9K20)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Follistatin like protein-1.
Antigenrecombinant human Follistatin like protein-1
ApplicationWB
SynonymsFST; FS
DescriptionFollistatin-like 1 (FSL1 or FSTL1), also known as FRP (follistatin-related protein), Flik (follistatin-like), and TSC36 (TGFβ1stimulated clone 36), is a secreted 45-55 kDa extracellular glycoprotein belonging to the BM40/ SPARC/Osteonectin family. The human FSTL1 cDNA encodes 308 amino acids (aa), including a 20 aa signal sequence, a cysteinerich Follistatin (EGF and kazal-like) domain, two apparently non-functional EF hand calciumbinding motifs, and a von Willebrand Factor C homology domain. Mature human FSTL1 shares 94%, 95%, 98%, and 99% aa identity with mouse, rat, bovine, and equine FSTL1, respectively. FSTL1 was first identified as a TGF-beta-induced protein from a mouse osteoblast cell line (4). It is ubiquitously expressed in early mouse development, but is mainly mesenchymal later in development. In humans, FSTL1 is a common rheumatoid arthritis autoantigen. It is reported to be either proinflammatory due to promoting inflammatory cytokine secretion, or to prevent autoimmune arthritis by inhibiting matrix metalloproteinase (MMP) and prostaglandin expression. In muscle and heart, it appears to be protective and promotes endothelial cell functions such as revascularization after ischemia, probably due to promoting expression and activation of the protein kinase AKT1.
Uniprot IDQ12841
Protein RefSeqNP_009016.1
mRNA RefSeqNM_007085.4

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