Mouse Anti-Human NGF-beta

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Size500 µg
Price275 €
CategoryMonoclonal Antibody
Species ReactivityHuman
Formulationlyophilized from PBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced in mice using highly pure (>98%) recombinant human beta-NGF as the immunizing antigen. This IgG2bK antibody was purified from cell culture by Protein G affinity chromatography.
AntigenRecombinant Human NGF-beta
ApplicationELISA, N, WB, IHC
SynonymsNGF; NGFB; HSAN5; Beta-NGF
Descriptionβ-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 14 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Uniprot IDP01138
Protein RefSeqNP_002497.2
mRNA RefSeqNM_002506

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