Mouse Anti-Human FGF-3

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Cat-Nr.101-M408
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#3F18)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of fibroblast growth factor receptor 3.
AntigenRecombinant human FGF-3
ApplicationWB, IHC (P), N
SynonymsFGF3; INT2; HBGF-3
DescriptionFibroblast Growth Factor 3 (FGF3) belongs to the large FGF family which has at least 23 members. All FGF family members are heparinbinding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. They act on cells of mesodermal and neuroectodermal origin to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects and tissue repair. Signaling receptors for FGFs are type I transmembrane receptor tyrosine kinases belonging to the Ig superfamily. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. Through alternative splicing, multiple isoforms for FGF R1, 2 and 3, with distinct ligand recognition profiles, are also generated. The FGF3 gene, originally designated int2, was first identified as a protooncogene activated in mouse mammary tumors by proviral integration.
Uniprot IDP11487
Protein RefSeqNP_005238.1
mRNA RefSeqNM_005247.2

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