Rat Anti-Mouse TNFSF11 beta

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Cat-Nr.103-M560
Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#7F37)
IsotypeIgG2
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
AntigenMouse recombinant protein TNFSF11
ApplicationWB
SynonymsTumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor (ODF); Osteoprotegerin ligand (OPGL), Receptor activator of nuclear factor kappa-B ligand (RANKL), TNF-related activation-induced cytokine (TRANCE)
DescriptionRANKL (Receptor Activator of NF-κB Ligand) is a protein of the tumor necrosis factor (TNF) family discovered in 1997 that is significantly involved in the regulation of bone remodeling. The protein is also known as TRANCE (TNF-related activation-induced cytokine), CD254, OPGL, and ODF. RANKL is secreted by, among others, osteoblasts (cells that build bone substance) and binds to the matching receptor RANK of monocytic osteoclast progenitor cells, inducing their differentiation into osteoclasts (cells that degrade bone substance again). The RANK/RANKL system is a biochemical regulatory circuit that causes bone resorption to remain in healthy balance with bone formation, which is a prerequisite for the dynamic architecture of the bone system. This system can be disturbed in various diseases and is therefore of practical interest to medicine. Translated with www.DeepL.com/Translator (free version)RANKL (Receptor Activator of NF-κB Ligand) is a protein of the tumor necrosis factor (TNF) family discovered in 1997 that is significantly involved in the regulation of bone remodeling. The protein is also known as TRANCE (TNF-related activation-induced cytokine), CD254, OPGL, and ODF. RANKL is secreted by, among others, osteoblasts (cells that build bone substance) and binds to the matching receptor RANK of monocytic osteoclast progenitor cells, inducing their differentiation into osteoclasts (cells that degrade bone substance again). The RANK/RANKL system is a biochemical regulatory circuit that causes bone resorption to remain in healthy balance with bone formation, which is a prerequisite for the dynamic architecture of the bone system. This system can be disturbed in various diseases and is therefore of practical interest to medicine. Translated with www.DeepL.com/Translator (free version)
Uniprot IDO35235
Protein RefSeqNP_035743.2
mRNA RefSeqNM_011613.3

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