Rat Anti-Mouse IL-3 receptor beta

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Cat-Nr.103-M253
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#42A7)
IsotypeIgG1
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-3R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigenrecombinant mouse protein of IL-3R beta extracellular domain
ApplicationWB
SynonymsCsf2rb2; Bil3; Il3r; AIC2A; Il3rb; Il3rb2; BetaIl3; Csfgmrb
DescriptionThe high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.
Uniprot IDP26954
Protein RefSeqNP_031807.1
mRNA RefSeqNM_007781.2

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