Mouse Anti-Human CD105/Endoglin

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Cat-Nr.101-M160
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#12J11)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with cell membrane glycoproteins of lymphoblastic leukemia cells. IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigencell membrane glycoproteins of lymphoblastic leukemia cells
ApplicationIHC
SynonymsEndoglin; END; ORW; HHT1; ORW1; CD105
DescriptionCD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-ß1 and ß3 with high affinity but not to TGF-ß2.
Uniprot IDP17813
Protein RefSeqNP_000109
mRNA RefSeqNM_000118

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