Rat Anti-Mouse Lyve-1
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| Cat-Nr. | 103-M130 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#4D17) |
| Isotype | IgG2 |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | Produced from a hybridoma fused by a mouse myeloma with B cells obtained from a rat immunized with mouse LYVE-1 recombinant protein. IgG2 fraction of the culture supernatant was purified by Protein G affinity chromatography. |
| Antigen | Mouse recombinant LYVE-1 |
| Application | WB, IHC (F) |
| Synonyms | Lyve1; Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik |
| Description | LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. |
| Uniprot ID | Q8BHC0 |
| Protein RefSeq | NP_444477 |
| mRNA RefSeq | NM_053247 |
Reference
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- Notch-Regulated c-Kit–Positive Liver Sinusoidal Endothelial Cells Contribute to Liver Zonation and Regeneration. Juan-Li Duan et al., Cell Mol Gastroenterol Hepatol. 2022; 13(6): 1741–1756.
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- An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. T. Majima et al., PLoS One. 2013; 8(6): e68134.
- Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. S. M. Zeisberger et al., Br J Cancer. 2006 Aug 7; 95(3): 272–281.
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