Mouse Anti-Human IL-3 receptor alpha

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Cat-Nr.101-M719
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#11A23)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human recombinant protein of IL-3R alpha extracellular domain. The IgG1 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigenrecombinant human IL-3 receptor alpha extracellular domain
ApplicationIHC, WB, N
SynonymsIL-3 R alpha, IL3ra
DescriptionInterleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
Uniprot IDP26951
Protein RefSeqNO_01254642.1
mRNA RefSeqNM_001267713.1

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