Mouse Anti-Mouse VEGF-A, Blocking Antibody
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| Cat-Nr. | mV1007m-m |
| Size | 100 µg |
| Price | 625 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#MAB0705) |
| Isotype | IgG1 |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified mouse VEGF). |
| Antigen | recombinant mouse VEGF |
| Application | N, WB |
| Synonyms | Vegfa; Vpf; Vegf; Vegf120; Vegf164; Vegf188 |
| Description | Mouse VEGF (or VEGF-A) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant murine VEGF (isoform 164) is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 164 amino acid polypeptide chains. The antibody blocks the binding of VEGF to VEGFR-2 ( mouse FLK) and therefore the initiation of signal transduction. |
| Uniprot ID | Q00731 |
| Protein RefSeq | NP_001020421 |
| mRNA RefSeq | NM_001025250 |
Reference
- Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. V. Kumar et al., Blood. 2010 Jun 10;115(23):4725-33.
- DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. I. Sörensen et al., Blood. 2009 May 28;113(22):5680-8.
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