Mouse Anti-Human VEGFR-2/KDR, Agonistic

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Cat-Nr.mV1001.3m-h
Size200 µg
Price520 €
CategoryMonoclonal Antibody
Clone Nr.(#8A01)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human VEGFR2 N-terminal fragment (AA N30-200)).
AntigenhVEGFR2 N-terminal fragment (N30-200)
ApplicationWB, IP, Activation of VEGFR-2
Synonymsvascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; kinase insert domain protein receptor
DescriptionVEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.
Uniprot IDP35968
Protein RefSeqNP_002244.1
mRNA RefSeqNM_002253.2

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