Rat Anti-Mouse Wnt-4

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Cat-Nr.103-M502
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#21D12)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Wnt-4.
Antigenrecombinant protein of Wnt-4
ApplicationWB
SynonymsWnt4; Wnt-4
DescriptionWnt-4 is a 38 - 42 kDa member of the Wnt family of secreted glycoproteins, which act as short-range signaling molecules via Frizzled receptors and a cascade of intracellular signals in vertebrate embryogenesis. Wnt-4 has been shown to play a critical role in the development of the reproductive system and in the formation of the kidneys, adrenals, pituitary gland, and mammary tissues. In the development of the reproductive system, Wnt-4 expression is down-regulated in the developing gonad after E11.5, although it persists in the developing ovary. Targeted deletion of Wnt-4 results in masculinization of XX mice, with rudimentary development of the masculine internal (Wolffian) ducts and degeneration of the female (Mullerian) reproductive tract. In addition to its involvement in urogenital development, Wnt-4 is also expressed in the perichondrium of the long bones, and promotes osteoblast differentiation. Wnt-4 may also be associated with abnormal proliferation in human breast tissue.
Uniprot IDP22724
Protein RefSeqNP_033549
mRNA RefSeqNM_009523

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