Mouse Anti-Human NKG2C

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Cat-Nr.101-M584
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#9R17)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of NKG2C.
Antigenrecombinant human NKG2C
ApplicationFC
SynonymsKLRC2; NKG2C; CD159c; NKG2-C
DescriptionNKG2A and NKG2C are type II transmembrane proteins with extracellular C-type lectin domains. These proteins heterodimerize with CD94 to form complexes that recognize HLA-E as ligand. The NKG2A/CD94 complex delivers an inhibitory signal resulting from ITIMs within the NKG2A cytoplasmic domain. NKG2C/CD94 provides an activating signal due to association with the ITAM-containing DAP12 adapter protein. These complexes are expressed on NK and T cell subsets.
Uniprot IDP26717
Protein RefSeqNP_002251.2
mRNA RefSeqNM_002260.3

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