Mouse Anti-Human NKp46

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Cat-Nr.101-M587
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#8F24)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of NKp46, also called NCR1 (natural cytotoxicity triggering receptor 1).
Antigenrecombinant human NKp46
ApplicationWB, IHC (F), FC
SynonymsNCR1; LY94; CD335; NKP46; NK-p46
DescriptionNKp30/NCR3, NKp44/NCR2, and NKp46/NCR1 are termed natural cytotoxicity receptors (NCR). These receptors are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp44 is induced upon activation of resting NK cells with IL-2 and can bind to viral hemagglutinins. NK-mediated dendritic cell (DC) recognition is highly dependent on engagement of NKp30 and may result in lysis of the DC.
Uniprot IDO76036
Protein RefSeqNP_004820.1
mRNA RefSeqNM_004829.6

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