Rat Anti-Mouse Lyve-1

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Cat-Nr.103-M130
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#4D17)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationProduced from a hybridoma fused by a mouse myeloma with B cells obtained from a rat immunized with mouse LYVE-1 recombinant protein. IgG2 fraction of the culture supernatant was purified by Protein G affinity chromatography.
AntigenMouse recombinant LYVE-1
ApplicationWB, IHC (F)
SynonymsLyve1; Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
DescriptionLYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Uniprot IDQ8BHC0
Protein RefSeqNP_444477
mRNA RefSeqNM_053247

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