Rat Anti-Mouse Kremen-1

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Cat-Nr.103-M261
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#6K45)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of Kremen-1 extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
AntigenMouse recombinant EC domain of Kremen-1
ApplicationWB
SynonymsKremen1; Krm1; Kremen; AV002070
DescriptionKremen (Kringle-containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Two related members, Kremen-1 and -2, have been identified. Kremens bind a subset of the secreted Dickkopf (Dkk) proteins with high affinity. The canonical Wnt signaling pathway receptor complex composed of Wnt, the seven-transmembrane domain receptor Frizzled, and the receptor-related protein 5/6 (LRP5/6) coreceptor, is modulated by Kremens and Dkk proteins.
Uniprot IDQ99N43
Protein RefSeqNP_115772.2
mRNA RefSeqNM_032396.3

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