Mouse Anti-Human Integrin alpha 6

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Cat-Nr.101-M519
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#2F37)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant Integrin a6 (also called CD49f). The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenrecombinant human Integrin alpha6
ApplicationIHC (F), FC
SynonymsITGA6; CD49f; VLA-6; ITGA6B
DescriptionIntegrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Uniprot IDP23229
Protein RefSeqNP_000201.2
mRNA RefSeqNM_000210.2

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