Mouse Anti-Human MIP-1 alpha

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Cat-Nr.101-M14
Size500 µg
Price250 €
CategoryMonoclonal Antibody
IsotypeIgG1, kappa
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute the antibody in sterile water to a concentration of 1.0mh/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced in BALB/c mice using highly pure (>98%) recombinant human MIP 1alpha as the immunizing antigen. This IgG1K antibody was purified from cell culture by Protein G affinity chromatography.
AntigenRecombinant Human MIP-1 alpha
ApplicationELISA, N
SynonymsCCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
DescriptionBoth MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Uniprot IDP10147
Protein RefSeqNP_002974.1
mRNA RefSeqNM_002983

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