Mouse Anti-Human Integrin alpha 2

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Cat-Nr.101-M515
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#2B13)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Integrin a2 (also called CD49b).
Antigenrecombinant human Integrin alpha2
ApplicationIHC (F), FC
SynonymsITGA2; BR; GPIa; CD49B; VLA-2; VLAA2; BDPLT9
DescriptionIntegrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Uniprot IDP17301
Protein RefSeqNP_002194.2
mRNA RefSeqNM_002203.3

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