Rabbit Anti-Rat VEGF-C

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Cat-Nr.104-PA10S
Size100 µg
Price150 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IG
Species ReactivityRat
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
PreparationProduced from sera of rabbits immunized with highly pure recombinant rat dNdC-VEGF-C. Anti-rat VEGF-C IgG was purified by affinity chromatography with immobilized Protein A.
AntigenRecombinant rat VEGF-C (RT #R20-015)
ApplicationWB, E
Synonymsvascular endothelial growth factor C; Vegfc
DescriptionVEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Uniprot IDO35757
Protein RefSeqNP_446105.1
mRNA RefSeqNM_053653.1

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