Rabbit Anti-Mouse TNF-alpha

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Cat-Nr.103-P35
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityMouse
Formulationlyophilized from PBS
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant mTNF-alpha. Anti-mTNF-alpha specific antibody was purified by affinity chromatography employing immobilized mTNF-alpha matrix.
Antigenrecombinant mouse TNF-alpha
ApplicationELISA, WB, N
SynonymsTnf; DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha
DescriptionTNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant murine TNF-α is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Uniprot IDP06804
Protein RefSeqNP_038721.1
mRNA RefSeqNM_013693.2

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