Rabbit Anti-Mouse VEGF-A
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|Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
|Stability and Storage
|The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
|Produced from sera of rabbits immunized with highly pure recombinant murine VEGF164. Anti-murine VEGF-A was purified by affinity chromatography with immobilized Protein A.
|Recombinant mouse VEGF164 (RT #M30-001)
|WB, IHC (P), E
|Vegfa; Vpf; Vegf; Vegf120; Vegf164; Vegf188
|Mouse VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant murine VEGF (isoform 164) is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 164 amino acid polypeptide chains.
- Erythropoietin Induces Lymph Node Lymphangiogenesis and Lymph Node Tumor Metastasis. Ae Sin Lee et al., Cancer Res. 2011 Jul 1;71(13):4506-17
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