Rabbit Anti-Human BDNF

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Cat-Nr.102-P02
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman, Mouse, Rat
Formulationlyophilized from PBS
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of goats pre-immunized with highly pure (>98%) recombinant human BDNF (human Brain-Derived Neurotrophic Factor). Anti-human BDNF specific antibody was purified by affinity chromatography employing immobilized human BDNF matrix.
AntigenE.coli derived Recombinant Human BDNF
ApplicationELISA, WB, N, IHC
SynonymsBDNF
DescriptionBDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
Uniprot IDP23560
Protein RefSeqNP_733931.1
mRNA RefSeqNM_170735.5

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