Rabbit Anti-Human Nanog

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Cat-Nr.102-P242
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human Nanog. Anti-Human Nanog specific antibody was purified by affinity chromatography employing immobilized human Nanog matrix.
AntigenRecombinant Human Nanog
ApplicationELISA, WB
SynonymsNANOG
DescriptionNanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of Nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of Nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, which maintains pluripotency and self renewal via a STAT3 independent pathway. Recombinant human Nanog is a 35 kDa protein, which is synthesized as a 304 amino acid polypeptide lacking a signal sequence for secretion.
Uniprot IDQ9H9S0
Protein RefSeqNP_079141.2
mRNA RefSeqNM_024865

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