Rabbit Anti-Human TIMP-1

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Cat-Nr.102-P252
Size100 µg
Price250 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human TIMP-1 (human Tissue Inhibitor of Metalloproteinases-1). Anti-Human TIMP-1 specific antibody was purified by affinity chromatography employing immobilized human TIMP-1 matrix.
Antigenrecombinant human TIMP-1
ApplicationELISA, WB
SynonymsTIMP1; EPA; EPO; HCI; CLGI; TIMP
DescriptionTIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Uniprot IDP01033
Protein RefSeqNP_003245
mRNA RefSeqNM_003254

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