Goat Anti-Human 4-1BB receptor
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| Cat-Nr. | 102-P100G |
| Size | 100 µg |
| Price | 265 € |
| Category | Polyclonal Antibody |
| Clone Nr. | Goat IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of goats pre-immunized with highly pure (>98%) recombinant human 4-1BB Receptor. Anti-Human 4-1BB Receptor specific antibody was purified by affinity chromatography employing immobilized h4-1BB Receptor matrix. |
| Antigen | highly pure (>98%) recombinant human 4-1BB Receptor |
| Application | ELISA, WB |
| Synonyms | TNFRSF9; ILA; 4-1BB; CD137; CDw137 |
| Description | 4-1BB (or human 4-1BBL receptor) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFR-SF9, CD137, and ILA. The 255 amino acid is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 kDa glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Crosslinking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co stimulatory signal that enhances the effect of other activating signals such as PHA or antiCD3 antibodies. 4-1BB signals through the TFAF2NIK pathway resulting in activation of NFκB and ultimately promoting proliferation and survival of T cells. |
| Uniprot ID | Q07011 |
| Protein RefSeq | NP_001552.2 |
| mRNA RefSeq | NM_001561 |
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