Rabbit Anti-Mouse Wnt-5a

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Cat-Nr.103-PA16
Size200 µg
Price290 €
CategoryPolyclonal Antibody
Species ReactivityMouse
Formulationlyophilized
AntigenRecombinant mouse Wnt-5a
SynonymsWnt-5a; Wnt5a; Wnt 5a; Wnt
DescriptionWnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to transform cells or signal through the canonical beta-catenin pathway that is so important in cancer, particularly colorectal cancer. Recent work in a wide range of human tumours has pointed to a critical role for Wnt-5a in malignant progression, but there is conflicting evidence whether Wnt-5a has a tumour-promoting or -suppressing role. Emerging evidence suggests that the functions of Wnt-5a can be drastically altered depending on the availability of key receptors. Hence, the presence or absence of these receptors may go some way to explain the conflicting role of Wnt-5a in different cancers.
Uniprot IDP22725
Protein RefSeqNP_033550.2
mRNA RefSeqNM_009524.3

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