Rabbit Anti-Mouse MIP-1 alpha

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Size100 µg
Price240 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityMouse
Formulationlyophilized from PBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (98%) recombinant murine MIP-1α. Anti-murine specific antibody was purified by affinity chromatography employing immobilized murine MIP-1α matrix.
AntigenRecombinant Mouse MIP-1 alpha
ApplicationELISA, WB
SynonymsCcl3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha
DescriptionBoth MIP-1 α and MIP-1 β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 α and MIP-1 β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 α selectively attracting CD8+ lymphocytes and MIP-1 β selectively attracting CD4+ lymphocytes. Additionally, MIP-1 α and MIP-1 β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 α and MIP-1 β are active on human and murine hematopoietic cells. Recombinant murine MIP-1 α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Uniprot IDP10855
Protein RefSeqNP_035467.1
mRNA RefSeqNM_011337.2

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