Rabbit Anti-Human FGF-23

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Cat-Nr.102-P109
Size100 µg
Price240 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized
BufferPBS
PreparationProduced from sera of rabbits immunized with highly pure Recombinant Human FGF-23. Anti-Human FGF-23-specific antibody was purified by affinity chromatography employing an immobilized Human FGF-23 matrix.
AntigenRecombinant human FGF-23
ApplicationELISA, WB
SynonymsFGF23; ADHR; HYPF; HPDR2; PHPTC ; fgf 23
DescriptionThe FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.
Uniprot IDQ9GZV9
Protein RefSeqNP_065689.1
mRNA RefSeqNM_020638

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