Rabbit Anti-Human BMP-2

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Cat-Nr.102-P03A
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman, Mouse, Rat
Formulationlyophilized from PBS
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBMP-2 (human BMP-2). Anti-hBMP-2 specific antibody was purified by affinity chromatography employing immobilized hBMP-2 matrix.
AntigenE.coli derived Recombinant Human BMP-2
ApplicationELISA, WB
Synonymsbone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
DescriptionHuman BMP-2 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor β (TGFβ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similarly to other TGFβ family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human, mouse and rat BMP2 are 100% identical. BMP2 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP 2 is a disulfidelinked homodimer of the carboxyterminal 114 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP2 have been shown to be mediated by the formation of heterooligomeric complexes of type I and type II serine/threonine kinase receptors. One BMP type II and two BMP type I receptors have been identified. In contrast to the TGFβ type I receptor, which does not bind the ligand in the absence of the TGFβ receptor type II, both BMP receptor type Is can bind BMP2 with highaffinity in the absence of BMP receptor type II.
Uniprot IDP12643
Protein RefSeqNP_001191
mRNA RefSeqNM_001200

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