Rabbit Anti-Human BMP-2

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Cat-Nr.102-PA106S
Size100 µg
Price170 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species Reactivityhuman BMP-4
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
PreparationAnti-human BMP-2/4 polyclonal serum was produced from sera of rabbits pre- immunized with a highly purified synthetic peptide of the human BMP-2/4 sequence (C-terminal amino acids “C(SH)-L-D-E-Y-D-K-V-V-L-K-N-Y-Q-E-M-V-V-E-G“). Anti-human BMP-2/4 polyclonal antiserum was purified by Protein A chromatography.
AntigenRecombinant human BMP-2 (RT# 200-002)
ApplicationWB, E
Synonymsbone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
DescriptionHuman Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. The antibody cross-reacts displays cross-reaction with human BMP-4 monomers in Western Blot.
Uniprot IDP12643
Protein RefSeqNP_001191
mRNA RefSeqNM_001200

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Reference

  1. An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2. G. Montagna et al., Front Bioeng Biotechnol. 2020; 8: 499.

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