Rabbit Anti-Rat VEGF-C

Slide this table

Cat-Nr.104-PA10S
Size100 µg
Price150 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityRat
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
PreparationProduced from sera of rabbits immunized with highly pure recombinant rat dNdC-VEGF-C. Anti-rat VEGF-C IgG was purified by affinity chromatography with immobilized Protein A.
AntigenRecombinant rat VEGF-C (RT #R20-015)
ApplicationWB, E
Synonymsvascular endothelial growth factor C; Vegfc
DescriptionVEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Uniprot IDO35757
Protein RefSeqNP_446105.1
mRNA RefSeqNM_053653.1

Figures


Reference

  1. Bone Marrow-Derived Mesenchymal Stem Cells Drive Lymphangiogenesis. L. Maertens et al., PLoS One. 2014; 9(9): e106976.
  2. Proteinuria Triggers Renal Lymphangiogenesis Prior to the Development of Interstitial Fibrosis. S. Yazdani et al., PLoS One. 2012; 7(11): e50209.

All prices plus VAT + possible delivery charges