Rabbit Anti-Human IL-4 receptor alpha, soluble

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Size100 µg
Price240 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
IsotypeRabbit IgG
Species ReactivityHuman
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationAnti-Human sIL-4 Receptor α-specific antibody was purified by affinity chromatography employing an immobilized-Human sIL-4 Receptor α matrix.
AntigenCHO cells derived Recombinant Human IL-4 Receptor α
ApplicationWB, ELISA
Synonymssoluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124
DescriptionIL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc).  The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα.  The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity.  It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. 
Uniprot IDP24394
Protein RefSeqNP_000409.1
mRNA RefSeqNM_000418

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