Rabbit Anti-Human Prox-1
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|Clone Nr.||Rabbit IgG|
|Buffer||0.5X PBS, pH 7.2|
|Reconstitution||Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.|
|Stability and Storage||The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.|
|Antigen||Recombinant human Prox-1 (RT #300-052)|
|Description||Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish lymphatic vessels from blood vessels. Prox-1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells. Produced from sera of rabbits immunized with the recombinant highly conserved C-terminal part of the homeobox transcription factor Prox-1.|
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- Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. I. Choi et al., Blood. 2011 Jan 6; 117(1): 362–365.
- CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. M. Kim et al., Cancer Res. 2010 Dec 15;70(24):10411-21.
- Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. E. Bazigou et al., Dev Cell. 2009 Aug; 17-2: 175–186.
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- Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Chang Min Yoon et al., Blood. 2008 Aug 15; 112(4): 1129–1138.
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