Goat Anti-Human CD40 Ligand

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Cat-Nr.102-P108G
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Goat IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of goats pre-immunized with highly pure (>98%) recombinant hsCD40L (human sCD40L). Anti-hsCD40L specific antibody was purified by affinity chromatography employing immobilized hsCD40L matrix.
AntigenRecombinant Human sCD40 Ligand
ApplicationELISA, WB
SynonymsCD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
DescriptionCD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site. CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78% amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes. Both membrane bound and soluble CD40L induce similar effects on B cells.
Uniprot IDP29965
Protein RefSeqNP_000065.1
mRNA RefSeqNM_000074.2

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