Rat Resistin

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Cat-Nr.R20-054
Size25 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 97% by SDS-PAGE & HPLC analyses
Length [aa]94
Molecular Weight20 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityData not available.
Species ReactivityRat
SynonymsRetn
DescriptionResistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin’s ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant rat Resistin is a 20.0 kDa disulfide-linked homodimeric protein composed of two 94 identical amino acid chains linked by a single disulfide bond.
Protein SequencePSMSLCPMDE AISKKINQDF SSLLPAAMKN TVLHCWSVSS RGRLASCPEG TTVTSCSCGS GCGSWDVRED TMCHCQCGSI DWTAARCCTL RVGS
Uniprot IDQ8K4J7
Protein RefSeqNP_653342.1
mRNA RefSeqNM_144741

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