Mouse FGF-23

Slide this table

Cat-Nr.M10-237
Size20 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 95% by SDS-PAGE & HPLC analyses
Length [aa]228
Molecular Weight25.5 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 μg/ml, in the presence of murine Klotho and heparin.
ReconstitutionCentrifuge the vial prior to opening!
SynonymsFibroblast Growth Factor 23,
DescriptionThe FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues.
Protein SequenceMYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTIYSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC KFRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLARRNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VSCSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV
Uniprot IDQ9EPC2
Protein RefSeqNP_072148.1
mRNA RefSeqNM_022657.4

All prices plus VAT + possible delivery charges