Mouse Prolactin

Slide this table

Cat-Nr.M10-127S
Size10 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]198
Molecular Weight22.5 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.
Species ReactivityRat, Human
SynonymsPrl; Prl1a1; AV290867
DescriptionProlactin (PRL) is a neuroendocrine pituitary hormone. Prolactin is synthesized by the anterior pituitary, placenta, brain, uterus, dermal fibroblasts, decidua, B cells, T cells, NK cells and breast cancer cells. Originally characterized as a lactogenic hormone, further studies have demonstrated broader roles in breast cancer development, regulation of reproductive function, and immunoregulation. In the immune system, Prolactin has been shown to be secreted by human PBMC and to act as a proliferative growth factor. Additionally, Prolactin treatment of human PBMC has been shown to enhance IFNγ production. In the breast, Prolactin-induced morphogenesis of the mammary cells is mediated through IGF2, which in turn up-regulates cyclin D1. Prolactin has several molecular forms. The predominant form is a monomer; the non-glycosylated form is 23 kDa and the glycosylated form is 25 kDa. Glycosylated Prolactin is removed from the circulation faster and has been reported to have lower biological potency. Mouse Prolactin cDNA encodes a 228 amino acid (aa) residue protein with a putative 31 aa residue signal peptide. The Prolactin receptor is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. B cells, T cells, macrophages, NK cells, monocytes, CD34+ progenitor cells, neutrophils, mammary gland, liver, kidney, adrenals, ovaries, testis, prostrate, seminal vesicles, and hypothalamus have all been shown to express the Prolactin receptor. Three forms of the receptor, generated by differential splicing, have been identified. These isoforms differ in the length of their cytoplasmic domains. It is believed that the short cytoplasmic form is non functional. Prolactin signal transduction involves the JAK/STAT families and Src kinase family.
Protein SequenceMLPICSAGDC QTSLRELFDR VVILSHYIHT LYTDMFIEFD KQYVQDREFM VKVINDCPTS SLATPEDKEQ ALKVPPEVLL NLILSLVQSS SDPLFQLITG VGGIQEAPEY ILSRAKEIEE QNKQLLEGVE KIISQAYPEA KGNGIYFVWS QLPSLQGVDE ESKILSLRNT IRCLRRDSHK VDNFLKVLRC QIAHQNNC
Uniprot IDP06879
Protein RefSeqCAA28018.1
mRNA RefSeqX04418.1

All prices plus VAT + possible delivery charges