Mouse GDF-5/CDMP-1

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Cat-Nr.M10-094
Size50 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]120
Molecular Weight27 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityThe ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
Species ReactivityMouse
ReconstitutionCentrifuge the vial prior to opening!
SynonymsGdf5; bp; brp; Cdmp-1
DescriptionGDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
Protein SequenceAPSATRQGKR PSKNLKARCS RKALHVNFKA PSATRQGKRP SKNLKARCSR KALHVNFKDM GWDDMGWDDW IIAPLEYEAF HCEGLCEFPL RSHLEPTNHA VIQTLMNSMD PESTPPTCCV PTRLSPISIL FIDSANNVVY KQYEDMVVES CGCR
Uniprot IDP43028
Protein RefSeqNP_032135.3
mRNA RefSeqNM_008109.3

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