Mouse IL-22

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Cat-Nr.M10-072
Size10 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]146
Molecular Weight33.4 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityAssay#1: Determined by its ability to activate STAT following receptor ligand interaction. Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 1.0-2.0 ng/ml.
Species ReactivityMouse
ReconstitutionCentrifuge the vial prior to opening!
SynonymsIL22; IL-22; Iltif; IL-22a; ILTIFa
DescriptionIL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 32-34 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
Protein SequenceMLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV
Uniprot IDQ9JJY9
Protein RefSeqNP_058667.1
mRNA RefSeqNM_016971

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