Mouse IL-12p80
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| Cat-Nr. | M10-048 |
| Size | 10 µg |
| Price | 170 € |
| Source | HEK 293 cells |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 313 monomer |
| Molecular Weight | 80 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12 p70 in T cell-enriched PBMCs. |
| Species Reactivity | Mouse |
| Synonyms | Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF, p40:Interleukin-12 subunit beta, IL-12 subunit p40, IL-12B, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), NK cell Stimulating Factor Chain 2 |
| Description | IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γproduction by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Murine IL-12 p80 is an 80.0 kDa, disulfide linked homodimer of two p40 chains of IL-12 that consists of 626 amino acid residues and less than 5% of the IL-12 p40 monomer |
| Protein Sequence | p40 Subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS |
| Uniprot ID | P43432 |
| Protein RefSeq | NP_001290173.1 |
| mRNA RefSeq | NM_001303244.1 |
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