Mouse IL-5

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Cat-Nr.M10-046S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]113
Molecular Weight26.2 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells and is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 10^5 units/mg.
Species ReactivityHuman, Mouse
ReconstitutionCentrifuge the vial prior to opening!
SynonymsIl5; Il-5; B-cell growth factor II Short name=BCGF-II Cytotoxic T-lymphocyte inducer Eosinophil differentiation factor T-cell replacing factor
DescriptionIL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.
Protein SequenceMEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Uniprot IDP04401
Protein RefSeqNP_034688.1
mRNA RefSeqNM_010558.1

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