Mouse MDC (CCL22)

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Cat-Nr.M10-033S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]68
Molecular Weight7.8 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to chemoattract human activated lymphocytes using a concentration of 10.0-100.0 ng/ml.
Species ReactivityHuman, Mouse
SynonymsCcl22; MDC; DCBCK; ABCD-1; Scya22
DescriptionMDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Protein SequenceGPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS
Uniprot IDO88430
Protein RefSeqNP_033163.1
mRNA RefSeqNM_009137.2

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