Mouse BD-3
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| Cat-Nr. | M10-023 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Length [aa] | 41 |
| Molecular Weight | 4.6 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Not available. |
| Species Reactivity | Mouse |
| Synonyms | Beta-Defensin 3, DEFB3, DEFB103A |
| Description | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-3 is a 4.6 kDa protein containing 41 amino acid residues. |
| Protein Sequence | KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K |
| Uniprot ID | Q9WTL0 |
| Protein RefSeq | NP_038784.1 |
| mRNA RefSeq | NM_013756.2 |
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