Mouse Amphiregulin
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Cat-Nr. | M10-019S |
Size | 10 µg |
Price | 95 € |
Source | E. coli |
Formulation | lyophilized |
Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses |
Length [aa] | 98 |
Molecular Weight | 11.3 kDa |
Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
Biological Activity | Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml. |
Species Reactivity | Mouse |
Synonyms | AR, AREG, Colorectum cell-derived growth factor (CRDGF) |
Description | Amphiregulin is an EGF-related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Murine Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues. |
Protein Sequence | SVRVEQVIKP KKNKTEGEKS TEKPKRKKKG GKNGKGRRNK KKKNPCTAKF QNFCIHGECR YIENLEVVTC NCHQDYFGER CGEKSMKTHS EDDKDLSK |
Uniprot ID | P31955 |
Protein RefSeq | NP_033834.1 |
mRNA RefSeq | NM_009704.4 |
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