Mouse IL-3

Slide this table

Cat-Nr.M10-015
Size10 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 96% by SDS-PAGE & HPLC analyses
Length [aa]135
Molecular Weight15.1 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.
Species ReactivityRat, Mouse, Human, Monkey, Bacteria, Gerbil
SynonymsIl3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu
DescriptionIL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
Protein SequenceMDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC
Uniprot IDP01586
Protein RefSeqNP_034686.2
mRNA RefSeqNM_010556.4

All prices plus VAT + possible delivery charges