Mouse IL-1 alpha

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Cat-Nr.M10-012S
Size2 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]159
Molecular Weight17.9 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
Species ReactivityMouse, Human, Rat
ReconstitutionCentrifuge the vial prior to opening!
SynonymsIl1a; Il-1a
DescriptionIL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1α is an 17.9 kDa protein containing 156 amino acid residues.
Protein SequenceSAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS
Uniprot IDP01582
Protein RefSeqNP_034684.2
mRNA RefSeqNM_010554

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