Human CoupTF2/NR2F2 (fragment)
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| Cat-Nr. | 400-026 |
| Size | 5 µg |
| Price | 110 € |
| Source | E. coli |
| Label | His-Tag |
| Formulation | lyophilized |
| Length [aa] | 197 |
| N Terminal Sequence | AMVVS |
| Species Reactivity | Human |
| Synonyms | COUP-TF2, Apolipoprotein A-I regulatory protein 1, ARP-1, COUP transcription factor II, COUP-TF II, Nuclear receptor subfamily 2 group F member 2 |
| Description | Tumor growth depends on nutrients and oxygen supplied by the vasculature through angiogenesis. It was shown that the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a member of the nuclear receptor family, is a major angiogenesis regulator within the tumor microenvironment. COUP-TFs consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). Conditional ablation of COUP-TFII in the tumor microenvironment severely compromised neoangiogenesis and lymphangiogenesis during pancreatic tumor progression and metastasis. It was shown that COUP-TFII plays a cell-autonomous role in endothelial cells to control blood vessel sprouting by regulating cell proliferation and migration. Mechanistic investigations revealed that COUP-TFII suppressed vascular endothelial growth factor receptor-2 (VEGFR-2/KDR) signaling by transcriptionally repressing the expression of VEGFR-1, thereby curtailing a central angiogenic driver of vascular growth. These results implicate COUP-TFII as a critical factor in tumor angiogenesis through regulation of VEGF/VEGFR-2 signaling, suggesting COUP-TFII as a candidate target for antiangiogenic therapy. |
| Protein Sequence | MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEL EHHHHHH |
| Uniprot ID | P24468 |
| Protein RefSeq | NP_066285.1. |
| mRNA RefSeq | NM_021005.3. |
Figures
SDS-PAGE analysis of recombinant human CoupTFII/NR2F2 fragment. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.
Western Blot Analysis of recombinant human CoupTF2/NR2F2 (fragment). The protein (5µg) was reconstituted in 500 µl 1X SDS sample buffer. Detection was performed using a polyclonal rabbit anti-human CoupTF2 antibody [Cat# 102-PA17]. As secondary antibody an AP-conjugated goat anti-rabbit antibody was used.
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